WebPhenytoin toxicity may result from intentional overdose, dosage adjustments, drug interactions, or alterations in physiology. Intoxication manifests predominantly as nausea, … WebClinical features of phenytoin overdose include neurological and gastrointestinal symptoms. Onset of symptoms is usually within 1 to 2 hours of ingestion, or within minutes if IV administration. There can be a delay by up to five days for the maximal effects following oral ingestion due to zero-order kinetics and prolonged absorption.
Phenytoin – An anti-seizure drug: Overview of its chemistry ...
WebJan 26, 2024 · Phenytoin is a commonly prescribed anticonvulsant used to treat most types of seizure disorders and status epilepticus, with the exception of absence seizures. Historically, phenytoin has been used as an antidysrhythmic agent, especially in the treatment of dysrhythmias due to digoxin toxicity. WebDiphenylhydantoin (Phenytoin) Diphenylhydantoin (Phenytoin) More information about Diphenylhydantoin. Chemical Status; ... 01/01/1988. Basis for Listing: SQE. Reproductive Toxicity; Listed as causing: Developmental Toxicity. Developmental Toxicity: Date of Listing: 07/01/1987. Basis for Listing: SQE. Cal EPA. Air Resources Board; Cal Recycle ... on抵抗 mosfet
Phenytoin poisoning - UpToDate
WebKey Points. Phenytoin intoxication is usually benign and symptoms are dose-related. Rapid IV administration may result in cardiac arrhythmias due to the propylene glycol contained … WebAug 1, 2024 · Toxicity relating to phenytoin can be a product of dose misuse, dose adjustment, an interaction with other drugs, or a patient's changing physiology (Kang et al., 2013; Srinivasan et al., 2015). The first symptoms of phenytoin intoxication are nausea, dysfunctions related to the central nervous system (such as ataxia or nystagmus), a … WebMay 1, 2007 · However, only unbound phenytoin has access to tissue sites that are responsible for phenytoin efficacy and toxicity. Thus, a total (bound + unbound) phenytoin concentration value—the result reported by most clinical laboratories as the "phenytoin level"—is an indirect measure of the pharmacologically active (unbound) concentration. on 異常犯罪捜査官 dailymotion